Outlier Doublebag
When I go on trips that last a few days or longer, I typically just throw my dirty clothes back into the suitcase, but on the opposite side from my clean clothes. I know I can't be the only one who does this, but that doesn't make it okay.
The Outlier Doublebag might solve this problem. It's essentially two bags in one, with openings at each end and a movable partition inside. The idea is, you start your trip with clean clothes packed at one end of the bag, and as they get dirty, they are put into the other end of the bag. This keeps the clean clothes from touching the used stuff and keeps you a little more organized.
Unfortunately, the Doublebag is out of stock at the moment, but Outlier has provided a sign-up link on the store page so you can be notified if/when it gets restocked. Maybe I'm an optimist, but I think that if more people sign up for these notifications, Outlier might get around to it quicker.
Of course, I would also keep an eye out for any deals that crop up around the web.