Tweetbot for Mac
Tweetbot is a well-known iOS Twitter client with loads of features like muting, iCloud sync and more, all powered by a beautiful and charming interface that only Tapbots could deliver.
Tweetbot for Mac brings all of that to the desktop. Complete with Retina support, multiple-column views and all of the great iOS features (including sync via iCloud), it's the best way for Mac nerds to use Twitter on their computers. It's available on the App Store for $19.